Find the cell you need

Circulating Tumor Cells

The ability to monitor the level and type of CTCs in a patient's blood provides rich information that is complementary and distinct from all other current diagnostic information. The isolation and purification of circulating tumor cells and the subsequent profiling of their biochemical changes, will greatly enhance both our understanding of cancer metastases, and in the assessment of experimental drugs/treatments.

Power of Enumeration

>90%

sensitivity

<10%

variation

Cellular Information

Proteomic

Biomarkers

Functional study

Genomic Information

Mutation detection

Whole genome

Gene expression

CTC enumeration has numerous potential applications include monitoring drug response/resistance, predicting the clinical outcome of cancer patients, or detecting potential metastasis early. However, CTC counts in cancer patients could be are incredibly low. 10 mL of blood may contain billions of RBCs, millions of leukocytes, and only one CTC.

Although detection, isolation, and analysis of CTCs has posed a challenge in the medical field, MiCareo has consistently achieved a 90% recovery efficiency with less than 10% variation lab tests.

And unlike many CTC enumeration technologies, MiSelect preserves the integrity of isolated cells, affording access to the complete range of genomic as well as cellular information.

Circulating Tumor Cells

The ability to monitor the level and type of CTCs in a patient's blood provides rich information that is complementary and distinct from all other current diagnostic information. The isolation and purification of circulating tumor cells and the subsequent profiling of their biochemical changes, will greatly enhance both our understanding of cancer metastases, and in the assessment of experimental drugs/treatments.

>90%

sensitivity

<10%

variation

Cellular Information

Proteomic

Biomarkers

Functional study

Genomic Information

Mutation detection

Whole genome

Gene expression

Power of Enumeration

CTC enumeration has numerous potential applications include monitoring drug response and resistance, predicting the clinical outcome of cancer patients, or detecting metastasis earlier. However, CTC counts in cancer patients can be are incredibly low. 10 mL of blood may contain billions of RBCs, millions of leukocytes, and only one CTC. Although detection, isolation, and analysis of CTCs has posed a challenge in the medical field, MiCareo consistently achieves better than 90% recovery efficiency with less than 10% variation in results.

Beyond Enumeration

Unlike many CTC imaging systems, the MiSelect R gives researchers the flexibility to access the complete range of genomic and cellular information using our SelectChip Retrieval.  Our gentle and minimal processing preserves the integrity of the isolated cells and delivers highly pure cells into a small volume microcentrifuge tube.

Rare Immune Cells

Monitoring treatment efficacy is increasingly difficult. Many checkpoint blockades are not found in tumor cells, but inhibitors are instead found acting upon immune cells such as cytotoxic CD8(+) T cells. Profiling immune cells may give more complete information as to cell response or resistance to experimental treatments.  

Isolation and Visualization

 Flow cytometry represents the gold standard for accurate determination of specific immune cells. However, as the rarity of the target cells falls to less than 1 in 100,000 background cells, it becomes more difficult to get accurate and absolute sorting and analysis using flow cytometry.

The MiSelect R System was developed specifically for rare cell isolation and identification including rare immune cell profiling. By using the eDAR process the MiSelect R System is able to sort and enrich rare immune cells from a background of whole blood.

The MiSelect R System shows greater sensitivity in isolating and quantifying rare immune cell subtypes, such as PD1 CD8 IFNγ TIM3 LAG3 positive T cells. In addition, MiSelect provides not only numerical data but high-dimensional imaging data for biomarker information.

Using this imaging data, it is possible to subtype rare immune cells. Using PD1, TIM3, LAG3 and IFNg, we can differentiate 16 subtypes of rare immune cells and discover their importance in IO treatments.

2-fold more sensitive than FACS at detecting immune cells

MiSelect high-dimensional imaging data

Other Rare Cells

The search for rare cells in precision medicine is not tied only to CTCs and tumor related immune cells. The potential application of MiCareo's technology is only limited by a researchers willingness to try to better understand rare cells and their uses.  We have developed an excellent tool for lighting the way to precision medicine.

Potential use cases

» Capture the complete genome of fetal cells to detect hereditary disease.

» Monitor auto-reactive T cells for a better

understanding of autoimmune diseases